On The Table Read Magazine, “the best book magazine in the UK“, in Dempsey Gray’s, Refuge in the Land Of Silver, James, a retired doctor, recognises the early stages of dementia in himself and shares memories with a young woman of her mother many years prior.
Refuge In The Land Of Silver
Refuge In The Land Of Silver by Dempsey Gray is a beautiful and authentic recounting of a retired doctor realising in himself the onset of dementia which explores how the decisions we make in a single moment can define our lives going forward, and how ultimately we need to be at peace with those paths we decided to tread.
Time and again, history comes back to haunt us. How we choose to deal with it often shapes our own happiness. Can we learn to live with our own decisions and the actions of others? Is there a difference between the need to know and the want to know?
James fights to hold on to memories, which are slowly but surely being stolen from him. Will he make peace with his past before it is too late? Can this happen through telling the story of someone he barely knows?
Will Lorena cope with what she discovers about her family history? Or will it destroy her and her loved ones?
Are you defined by the sins of your forefathers?
A read that is made all the more heartrending on learning that this book was written as a tribute to the author’s own mother’s fortitude and bravery throughout her dementia journey, Dempsey Gray writes as one comfortable in their own skin and with a unique style that will have readers seeking out everything she writes going forward.
A beautiful recounting of the inevitable outcome of a ravaging disease, Refuge in the Land of Silver is destined to find a place in the hearts of all that pick up a copy.
Dempsey Gray
Sadly my Mum had dementia and after she passed away I wrote this story as a tribute to her bravery and also to help others understand that sometimes you just can’t see what is happening right under your nose until it is too late.
-Dempsey Gray
Dempsey Gray grew up in Sharjah, UAE and has since lived in Andorra, France and Spain. She and her husband Martin live with their rescued pet terrapin, Terry, who dominates the garden near Chichester, West Sussex.
With a love of travel, particularly Latin America, she takes every opportunity to meet people, enjoy local food, wine, culture and scenery of all new places she travels to. She speaks French and Spanish and is a qualified soft tissue therapist.
Find more from Dempsey Gray now:
Kindle: https://amzn.to/3w8efeJ
Paperback: https://amzn.to/3w7PRdc
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Colitis, as a persistent and recurrent inflammatory bowel ailments with limited therapeutic outcomes,
is characterised by immune problems and intestinal barrier dysfunction. Fortuitously,
carrier-free nanodrug as a newly- promising platform has been widely utilized.
The body produces BPC-157, also referred to as Physique Defending Compound, in minute quantities inside
gastric juices. Its role is to safeguard and promote healing
in both the higher and lower sections of the gastrointestinal (GI)
tract. For this cause, BPC-157 peptide therapy is useful within the therapy of ulcers, esophageal irritation, and symptoms
of inflammatory bowel illness.
This mechanism explains the peptide’s ability
to supply long-lasting therapeutic effects even after therapy discontinuation.
Zeng et al. (2025) performed pivotal research demonstrating the peptide’s function in treating vitiligo via targeted melanocyte protection. Their examine revealed that melanocyte-specific delivery utilizing
modified liposomes carrying therapeutic compounds considerably alleviated vitiligo improvement in mouse models.
KPV has been proven to decrease the expression of key pro-inflammatory
cytokines similar to IL-6, IL-12, IL-1β, TNF-α, and IFN-γ.
This effect was noticed each in vitro and in vivo,
indicating its potential as a potent anti-inflammatory agent.
Notably, KPV did not enhance the degrees of anti-inflammatory cytokines like IL-10, suggesting that its primary mechanism is the reduction of pro-inflammatory alerts.
We usually embrace details about a peptide’s timeline of benefits, but to do the identical with KPV would require an unreasonable amount of unhelpful conjecture.
In addition, with its origins in α-MSH, KPV has demonstrated therapeutic worth associated to immune function, namely
antimicrobial and wound-healing potential.
Α-MSH and other melanocortin peptides are potent anti-inflammatory agents
and have been proven to be effective in many ailments (30).
Here, we demonstrate that the tripeptide KPV, which is
the C-terminal sequence of α-MSH, has an anti-inflammatory impact
in vitro and in vivo. We present that the anti-inflammatory effect of KPV is not melanocortin receptor-mediated however PepT1-mediated.
This is most likely going due to its anti-inflammatory and
antimicrobial properties, which might help struggle off
any harmful pathogens which will enter the wound and reduce inflammation within the area.
Physique Protection Compound 157 (BPC-157) is a peptide consisting of a particular sequence of amino acids extracted from human gastric
juice. It has been extensively studied for its regenerative properties,
notably in healing injuries and ulcers within the gastrointestinal tract.
Derived from a naturally occurring protein in the abdomen, BPC-157 promotes rapid tissue restore, reduces inflammation, and accelerates recovery from injuries.
Whether you’re dealing with muscle tears, ligament harm, or continual ache, BPC-157 helps your body’s pure therapeutic processes,
helping you recuperate sooner and get back to peak efficiency.
It has been discovered that KPV can inhibit cancer cell growth and enhance the effectiveness of chemotherapy medicine.
NCM460 cells, characterised by low PepT1 expression,
and Caco-2 cells, characterised by excessive PepT1 expression,
have been utilized to study the focusing on efficacy of
the NPs. Initially, the expression levels of the PepT1 gene (Figure
2A) and protein (Figure 2B) were confirmed in both
NCM460 and Caco-2 cell traces. Subsequently, the intracellular
focus of FK506 was measured by HPLC after the NPs were incubated with the 2 cell sorts.
Chemokine signaling from airway epithelium regulates macrophage recruitment to the lung in inflammatory diseases corresponding to bronchial asthma.
For instance, one animal examine found that KPV aided within the
recovery of animals suffering from a stroke. In explicit, a number of
studies have reported success in providing KPV before and through
ischemia, which is when blood circulate is lowered to the brain. The research means that KPV could struggle in opposition to ischemic brain injury by reducing the levels of proinflammatory cytokines within the brain. It may
help to cut back the scale of lifeless tissue that results from ischemia.
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References:
https://docs.juze-cr.de/HZ5J7Oo3RSSko5rljQpvow/